RGX-104 HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RGX-104 是一种肝脏 X 受体 (LXR) 激动剂，具有潜在的免疫调节和抗肿瘤活性。它通过 ApoE 基因的转录激活来调节先天免疫。

RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.(In Vivo):Oral administration of GW3965 or RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Strong tumor growth suppression is also observed in animals bearing large tumors. In some instances, the treatment causes partial or complete tumor regression. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer.

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Oral administration of GW3965 or RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Strong tumor growth suppression is also observed in animals bearing large tumors. In some instances, the treatment causes partial or complete tumor regression. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer.

SB742881

Others

Other Targets

LXR

Cancer

Lymphoma; Solid tumours

610318-03-1

632.54

C34H34Cl2F3NO3

>98% (HPLC)

DMSO: 115 mg/mL (181.81 mM)

Cl.C[C@H](CCOc1cccc(CC(O)=O)c1)N(CC(c1ccccc1)c1ccccc1)Cc1cccc(c1Cl)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years